Università degli Studi di Pavia - Faculty of Science


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Molecular Pharmacology

Federico Forneris

Course content

Molecular Pharmacology addresses the study of the molecular mechanisms and biological consequences of the interactions of drugs and other small molecules with biological targets. The course will comprehensively explore the topics of modern molecular pharmacology with a strong focus on the structure-function relationships that enable the specific interactions between drugs and their biological targets. The material covered by this course include: i) modern biophysical and structural approaches to study molecular interactions; ii) basic principles of drug-receptor interactions; iii) structure-based drug design iv) principles of pharmacokinetics and pharmacodynamics; v) pharmacogenetics and pharmacogenomics; vi) structural biology of drug targets: GPCRs, signaling complexes, kinases, with examples of interacting drugs as tools to achieve knowledge of cell macromolecular structure and function; vii) mechanism of action of various drugs commonly used in clinical practice; viii) therapeutic potential of biotechnological drugs (ranging from biologicals, such as recombinant proteins and humanized monoclonal antibodies, to nucleic acids, such as oligodeoxynucleotides, ribozymes, modified siRNAs); ix) strategies to overcome possible drawbacks associated with use of biotech drugs; x) modern approaches to molecular pharmacology (molecular engineering, gene therapy, and drug delivery).

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