Università degli Studi di Pavia - Faculty of Science

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Bioinformatics

Teachers:
Silvia Bione, Davide Sassera
Year:
2016/2017
ECTS:
6
SSD:
ING-INF/06

Course content

Aim of the course is to provide students with the basic knowledge of bioinformatic methodologies, tools and approaches that are essential to integrate molecular biology and genetics studies and researches.


Course content.
Functions and goals of Bioinformatics. NCBI and EBI sites. Query tools for integrated databases. Biomedical primary and derivative databases. Sequence comparison: basic notions and alignment tools. Multiple sequences alignment and evolutionary clustering. Genome Browsers. Regulatory elements in genome browsers. Transcriptional profiles in genome browsers and database. Analysis of nucleotide variations and repeated sequences. Human dfiseases and mutations. Bioinformatic analysis of alternative splicing. Bioinformatic analysis of microRNA targets.


Laboratories.

Finding information in biomedical databases. Tools for sequence comparison. The human UCSC genome browser. The architecture of regulatory elements. Making SNPs and repetitive sequences make sense. Data mining in gene lists. Analysis of gene regulation: alternative splicing and microRNA analysis


Credits: apnetwork.it