Università degli Studi di Pavia - Faculty of Science


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Silvia Bione

Academic position:
Assistant Professor
bione (at) igm.cnr.it
Phone number:
+39 0382 546340
+39 0382 422286





No exams

Curriculum vitae

Silvia Bione, PhD
Born April 15th, 1968
1997: PhD degree in Genetic Sciences at University of Pavia
1993: Graduated with honors in Biological Sciences at University of Pavia
Professional experience
2001-today: Staff scientist at Molecular Genetics Institute-CNR, Pavia
1998: Visiting Scientist at Stanford University, CA USA
1993-2001: Research Fellowship activities at Molecular Genetics Institute-CNR, Pavia
Research activity
The comprehension of molecular mechanisms involved in the pathogenesis of human diseases with a complex, multifactorial genetic inheritance, requires today bioinformatic and biostatistic approaches able to integrate and interpret the huge amount of informations derived from genome-wide studies. Recent technological improvements, that have made possible the analysis of human diversity at different molecular levels, resulted in the development of new strategies in human genetic studies aimed at the identification of genetic determinants, at the comprehension of their interactions and of molecular mechanisms involved in susceptibility to complex disorders. The study of these genetic determinants requires today the use of suitable bioinformatic and biostatistic approaches and the development of new methodologies for the comprehension of complex biological systems regulating normal and pathological human physiology.
To this aim, the goal of ongoing studies is the the application of new biostatistic and bioinformatic tools for
-the identification of genetic determinants involved as risk-factors in cardiovascular disorders, in particular in stroke
-the identification of anomalies in molecular pathways, as gene-expression or alternative splicing, acting as susceptibility factors for complex diseases.
Selected pubblications
  1. Rossetti R, Di Pasquale E, Marozzi A, Bione S, Toniolo D, Grammatico P, Nelson LM, Beck-Peccoz P, Persani L. BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein. Hum Mutat. 2009 May;30(5):804-10.
  2. Corre T, Schuettler J, Bione S, Marozzi A, Persani L, Rossetti R, Torricelli F, Giotti I, Vogt P, Toniolo D; Italian Network for the study of Ovarian Dysfunctions. A large-scale association study to assess the impact of known variants of the human INHA gene on premature ovarian failure. Hum Reprod. 2009 Aug;24(8):2023-8.
  3. Traglia M, Sala C, Masciullo C, Cverhova V, Lori F, Pistis G, Bione S, Gasparini P, Ulivi S, Ciullo M, Nutile T, Bosi E, Sirtori M, Mignogna G, Rubinacci A, Buetti I, Camaschella C, Petretto E, Toniolo D. Heritability and demographic analyses in the large isolated population of Val Borbera suggest advantages in mapping complex traits genes. PLoS One. 2009 Oct 22;4(10):e7554.
  4. Sorice R, Bione S, Sansanelli S, Ulivi S, Athanasakis E, Lanzara C, Nutile T, Sala C, Camaschella C, D'Adamo P, Gasparini P, Ciullo M, Toniolo D. Association of a variant in the CHRNA5-A3-B4 gene cluster region to heavy smoking in the Italian population. Eur J Hum Genet. 2011 May;19(5):593-6.
  5. Ostano P, Bione S, Belgiovine C, Chiodi I, Ghimenti C, Scovassi AI, Chiorino G, Mondello C. Cross-analysis of gene and miRNA genome-wide expression profiles in human fibroblasts at different stages of transformation. OMICS. 2012 Jan-Feb;16(1-2):24-36.
  6. Cheng YC, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, Rasheed A, Zeginigg M, Attia J, Baker R, Barlera S, Biffi A, Bookman E, Brott TG, Brown RD Jr, Chen F, Chen WM, Ciusani E, Cole JW, Cortellini L, Danesh J, Doheny K, Ferrucci L, Grazia Franzosi M, Frossard P, Furie KL, Golledge J, Hankey GJ, Hernandez D, Holliday EG, Hsu FC, Jannes J, Kamal A, Khan MS, Kittner SJ, Koblar SA, Lewis M, Lincz L, Lisa A, Matarin M, Moscato P, Mychaleckyj JC, Parati EA, Parolo S, Pugh E, Rost NS, Schallert M, Schmidt H, Scott RJ, Sturm JW, Yadav S, Zaidi M, Boncoraglio GB, Levi CR, Meschia JF, Rosand J, Sale M, Saleheen D, Schmidt R, Sharma P, Worrall B, Mitchell BD; GARNET Collaborative Research Group; GENEVA Consortium; International Stroke Genetics Consortium. Are myocardial infarction-associated single-nucleotide polymorphisms associated with ischemic stroke? Stroke. 2012 Apr;43(4):980-6.
  7. Parolo S, Lisa A, Gentilini D, Di Blasio AM, Barlera S, Nicolis EB, Boncoraglio GB, Parati EA, Bione S. Characterization of the biological processes shaping the genetic structure of the Italian population. BMC Genet. 2015 Nov 9;16:132. doi: 10.1186/s12863-015-0293-x.
  8. Bluher A, Devan WJ, Holliday EG, Nalls M, Parolo S, Bione S, Giese AK, Boncoraglio GB, Maguire JM, Müller-Nurasyid M, Gieger C, Meschia JF, Rosand J, Rolfs A, Kittner SJ, Mitchell BD, O'Connell JR, Cheng YC. Heritability of young- and old-onset ischaemic stroke. Eur J Neurol. 2015 Nov;22(11):1488-91. doi: 10.1111/ene.12827.
  9. Cremaschi P, Carriero R, Astrologo S, Colì C, Lisa A, Parolo S, Bione S. An Association Rule Mining Approach to Discover lncRNAs Expression Patterns in Cancer Datasets. Biomed Res Int. 2015;2015:146250. doi: 10.1155/2015/146250.
  10. Cremaschi P, Rovida S, Sacchi L, Lisa A, Calvi F, Montecucco A, Biamonti G, Bione S, Sacchi G. CorrelaGenes: a new tool for the interpretation of the human transcriptome. BMC Bioinformatics. 2014;15 Suppl 1:S6. doi: 10.1186/1471-2105-15-S1-S6.

Credits: apnetwork.it