Università degli Studi di Pavia - Faculty of Science


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Gianni Francesco Guidetti

Academic position:
Assistant Professor
gianni.guidetti (at) unipv.it
Phone number:
+39 0382 987241
+39 0382 987240
Department of Biology and Biotechnology "Lazzaro Spallanzani"


Methods in Biochemistry
Methods in Biochemistry
Methods in Biochemistry


No exams

Curriculum vitae

Gianni Guidetti obtained the degree in Biological sciences in 2000 and the PhD in Biochemistry and Molecular Physiology in 2004 at the University of Pavia. From October 2002 to March 2003 he joined the research group led by Professor J.L. Bos at the Department of Physiological Chemistry, University Medical Centre, Utrecht, The Netherlands. During that period of time he investigated the role of Ras-GTPases in cancer. From 2004 to 2008 he worked as a Post-doc researcher at the department of Biochemistry of the University of Pavia. Since December 2008 he holds a position of assistant professor at the Department of Biology and Biotechnology, University of Pavia. Since 2017 he is a member of the teaching board in the PhD program in Biomedical Sciences of the University of Pavia. Main research interests: Biochemical mechanisms of signal transduction in platelet activation. Effects of nanomaterials and nanoparticles on platelet function. Platelet-tumor interactions and contribution of platelets and platelet-derived microparticles (PMPs) to tumor growth and metastasis.
Selected publications
  1. Guidetti GF, Zarà M, Canobbio I, Visconte C, Di Nunzio G, Torti M. Novel pharmacological inhibitors demonstrate the role of the tyrosine kinase Pyk2 in adhesion and aggregation of human platelets. Thromb Haemost. 2016;116:904-917.
  2. Guidetti GF, Canobbio I, Torti M. PI3K/Akt in platelet integrin signaling and implications in thrombosis. Adv Biol Regul. 2015.pii: S2212-4926(15)30005-1.
  3. Guidetti GF, Manganaro D, Consonni A, Canobbio I, Balduini C, Torti M Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca(2+)-dependent activation of platelet Rap1b GTPase. Biochem J. 2013;453:115-23.
  4. Guidetti GF, Consonni A, Cipolla L, Mustarelli P, Balduini C, Torti M . Nanoparticles induce platelet activation in vitro through stimulation of canonical signalling pathways. Nanomedicine. 2012;8:1329-36. doi:10.1016/j.nano.2012.04.001; PMID: 22542822.
  5. Consonni A, Cipolla L, Guidetti GF, Canobbio I, Ciraolo E, Hirsch E, Falasca M, Okigaki M, Balduini C, Torti M. Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling. Blood. 2012;119:847-56.
  6. Guidetti GF, Bernardi B, Consonni A, Rizzo P, Gruppi C, Balduini C, Torti M. Integrin 21-induced tyrosine phosphorylation-independent activation of phospholipase C2 in adherent platelets: a role for Rac GTPases. J Thromb Haemost. 2009;7:1200-6.
  7. Guidetti GF, Lova P, Bernardi B, Campus F, Baldanzi G, Graziani A, Balduini C, Torti M. The Gi-coupled P2Y12 receptor regulates diacylglycerol-mediated signaling in human platelets. Journal of Biological Chemistry 2008,283:28795-28805.
  8. Bernardi B, Guidetti GF, Campus F, Crittenden JR, Graybiel AM, Balduini C, Torti M. The small GTPase Rap1b regulates the cross-talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3. Blood 2006, 107: 2728-2735.
  9. Guidetti GF, Greco F, Bertoni A, Giudici C, Viola M, Tenni R, Tira EM, Balduini C and Torti M. Platelet interaction with CNBr peptides from type II collagen via integrin alpha2beta1. BBA molecular cell research 2003, 1640: 43-51.
  10. Guidetti GF, Bertoni A, Viola M, Tira E, Balduini C, Torti M. The small proteoglycan decorin supports adhesion and activation of human platelets. Blood 2002, 100: 1707-1714.


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