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Donata Orioli

Academic position:
Assistant Professor
E-mail:
orioli (at) igm.cnr.it
Phone number:
0382 546331 (laboratory)/0382 546345 (office)
Fax:
0382 422286
Website:
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Department:
IGM-CNR

Courses

2016/2017
Molecular Genetics

Exams

No exams

Curriculum vitae

Curriculum Vitae

Graduated cum laude in Biological Sciences at the University of Pavia, she performed her PhD in Biological Science at the European Molecular Biology Laboratory (EMBL) of Heidelberg-Germany, under the supervision of Dr. R. Klein. She has been an EMBO long-term postdoctoral Fellow at the Institute of Molecular Genetics (IGM) CNR of Pavia and subsequently the Principal investigator of the Telethon research project “Identification of Rac3-interacting proteins during neuritogenesis”. Since 2003, she is member of the research unit leaded by Dr. M. Stefanini at the IGM CNR. The research is supported by the Italian Ministry of Education, University and Research (MIUR), the European Community, Cariplo Foundation and the Italian Association for Cancer Research (AIRC). Since September 2009 she is CNR researcher at the IGM CNR Pavia and leader of a research project sponsored by CNR/CNRS (2010-2011).

 

Academic activity

1999: Teaching contract at the University of Bologna (Scuola di Specialità in Genetica Applicata). 2005-2009: Teaching contract at the University of Pavia (Corso di Laurea Specialistica in Biologia Sperimentale Applicata).

Since 2010: Teaching contract at the University of Pavia (Corso di laurea Magistrale in Molecular Biology and Genetics).

 

Research activity

She has extensive experience in the field of molecular biology and biochemistry, with special emphasis on nervous system development in mammals. During the PhD, she identified the in vivo function of several tyrosine kinase receptors during nervous system development by using the mouse gene targeting approach. Later on, her research has been focusing on the human syndromes xeroderma pigmentosum (XP), trichothiodistrophy (TTD) and Cockayne Syndrome (CS), which result from defects in nucleotide excision repair (NER), a versatile DNA repair system that removes a wide range of lesions, including UV photoproducts. The clinical features of these disorders are very different: XP is a highly cancer-prone disease, whereas TTD and CS are cancer-free multisystem disorders characterised by defects in physical and mental development, premature ageing and alterations in the immune and nervous systems. The photosensitive form of TTD is due to alterations in the XPB, XPD or TTDA genes that encode subunits of the repair/transcription complex TFIIH. By micro-array technology, she evaluated the gene expression profiles in primary fibroblasts from patients mutated in the XPD gene. This study allowed the identification of a limited number of “disease-specific” genes that are currently under investigation.

 

Relevant Publications

Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R, and Lemke G. (1995) Aberrant neuronal and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature, 378: 390-394. IF (1997) 27.368

Henkemeyer M, Orioli D, Henderson JT, Saxton TM, Roder J, Pawson T and Klein R. (1996) Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell, 86: 35-46. IF (1997) 37.297

Orioli D, Henkemeyer M, Lemke G, Klein R and Pawson T. (1996) Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J, 15: 6035-6049. IF (1997) 12.643

Orioli D and Klein R. (1997) The Eph receptor family: axonal guidance by contact repulsion. Trends in Genetics, 13: 354-359. IF (1997) 9.978 

Orioli D, Colaluca IN, Stefanini M, Riva S, Dotti GC and Peverali AF. (2006) Rac3-induced neuritogenesis requires the binding to Neurabin I. Molecular Biology of the Cell, 17: 2391-2400. IF (2006) 6.562

Paulis M, Bensi M, Orioli D, Mazzini G, D’Incalci M, Falcioni C, Radaelli E, Mondello C, Raimondi E and De Carli L. (2007) Transfer of a human chromosomal vector from a hamster cell line to a mouse embryonic stem cell line. Stem Cell, 10: 2543-2550. IF (2007) 7.531

Yasuda G, Watanabe E, Nishi R, Mori T, Iwai S, Orioli D, Stefanini M, Hanaoka F and Sugasawa K (2007) In vivo instability and functional defects of XPC protein caused by a pathogenic missense mutation. Mol Cell Biol, 19: 6606-6614. IF (2007) 6.420

Botta E, Nardo T, Orioli D, Guglielmino R, Ricotti R, Bondanza S, Benedicenti F, Zambruno G, Stefanini M. (2009) Genotype-phenotype relationships in trichothiodystrophy patients with novel splicing mutations in the XPD gene. Hum Mutat, 30: 438-445. IF (2009) 6.887

Nardo T, Oneda R, Spivak G, Vaz B, Mortier L, Thomas P, Orioli D, Laugel V, Stary A, Hanawalt PC, Sarasin A, Stefanini M. (2009) A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage. Proc Natl Acad Sci USA, 106: 6209-6214. IF (2009) 9.432

Stefanini M, Botta E, Lanzafame M and Orioli D. (2010) Trichothiodystrophy: from basic mechanisms to clinical implications. DNA Repair, 9: 2-10. IF (2009) 4.199

 

 

Credits: apnetwork.it