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Andrea Mattevi

Academic position:
Full Professor
E-mail:
andrea.mattevi (at) unipv.it
Phone number:
+39 0382 985525 (office): +39 0382 985535 (lab)
Fax:
+39 0382 528496
Website:
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Department:
Department of Biology and Biotechnology "Lazzaro Spallanzani"

Courses

2016/2017
Structural Biology and Pharmacology

Exams

No exams

Curriculum vitae

Proteins at Work: Understanding the Chemical Secrets of Life.

The main task for many proteins inside living cells is to catalyse (accelerate) chemical reactions. Proteins having such a catalytic function are called enzymes. A common theme to most of my research projects has been the investigation of medically relevant enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual functions. The core of the research activity is represented by X-ray crystallography, which is the main technique to study the three-dimensional structure of biological macromolecules. This is, however, complemented by other approaches such as site-directed mutagenesis, analysis of enzyme kinetics and computational chemistry. The picture shows a recent result from our lab; the elucidation of the structure of a complex of three proteins that are involved in the regulation of gene expression.



Further reading

Chaiyen, P., Fraaije, M.W., Mattevi, A. (2012) The enigmatic reaction of flavins with oxygen Trends Biochem. Sci., in press

Baron, R., Binda, C., Tortorici, M., McCammon, J.A., Mattevi, A. (2011) Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase LSD1 – CoREST Complex. Structure
19, 212-220

Orru, R., Dudek, H.M., Martinoli, C., Torres Pazmino, D.E., Royant, A., Weik, M., Fraaije, M.W., Mattevi, A. (2011) Snapshots of enzymatic baeyer-villiger catalysis: oxygen activation and intermediate stabilization. J. Biol. Chem. 286, 29284-29291

De Colibus, L., Mattevi. A. (2006) New frontiers in flavoenzyme structure and mechanism. Curr. Opin. Struc. Biol. 16, 722-728

Forneris, F., Binda, C., Battaglioli, E., Mattevi, A. (2008) LSD1: Oxidative Chemistry for Multifaceted Functions in Chromatin Regulation. Trends Biochem. Sci. 33, 181-189.

Forneris F., Mattevi, A. (2008) Enzymes Without Borders: Mobilizing Substrates, Delivering Products. Science 321, 213-216

 

Website: www.unipv.it/biocry 

Credits: apnetwork.it